Founding Scientist (Synthetic Genomics)

About Exonic

Exonic is an AI-native cell and gene therapeutics company.

Tech

We train multimodal biological foundation models on large-scale heterogeneous biological datasets to design synthetic non-coding DNA. We experimentally validate our AI-designed systems in mammalian cells, with current applications in cell-type targeting and viral vector biomanufacturing.

The role

**Exonic Biosciences · Dogpatch, San Francisco****$120K–$180K a year + equity**Exonic is building AI systems for programmable biology.We train multimodal foundation models on large-scale biological datasets to design synthetic non-coding DNA. We experimentally validate our AI-designed systems in mammalian cells, with current applications in cell-type targeting and viral vector biomanufacturing.Our core focus is synthetic regulatory DNA. We have already generated strong in vitro cell-type targeting results and are expanding our internal experimental platform in San Francisco.We are looking for an ambitious experimental scientist to take ownership of Exonic’s wet-lab work and help push the platform into new directions.You would work directly with the founder as one of the first people in the company.**What you’ll work on*** Own and execute experimental validation of AI-designed regulatory DNA* Design and run cell-based assays for synthetic enhancer and expression systems* Help advance programs in cell-type targeting and AAV manufacturing* Help shape Exonic’s experimental roadmap as the company grows**Relevant experience*** Molecular biology, synthetic biology, regulatory genomics, or gene therapy* Mammalian cell culture and cell-based assays* Cloning, plasmid design, transfection, qPCR/ddPCR, sequencing, flow, luciferase, or related workflows* AAV biology/manufacturing experience is a major plusWe care most about ownership, execution speed, and comfort with ambiguity.This is an early-stage role with autonomy, and the opportunity to build the biological engine of an AI-native synthetic DNA company.**Location:** San Francisco / MBC BioLabs

Skills

• Cell biology
• Molecular biology
• Wet lab
• Biology