TM
Scientist II - LNP Formulation
Tailored Management
- 🇺🇸 United States
- On-site
- 1 day ago
- $43 – $48 / hour
- Excel
1 day ago
Not enough detail in this posting to match
Work Location: San Diego, CA. 92111
Schedule: Onsite, Mondays to Fridays
Starting Pay Rate: $43- $48 per hour
Position Overview
We are seeking a Scientist II to join our Formulation team, supporting the development and optimization of lipid nanoparticles (LNPs) for nucleic acid delivery. This hands-on laboratory role focuses on the formulation, encapsulation, and characterization of targeted and non-targeted LNPs containing mRNA, siRNA, or DNA for in vitro and in vivo applications.
The successful candidate will execute formulation experiments, conduct Design of Experiments (DoE)-based screening campaigns, analyze experimental data, and collaborate with cross-functional teams to advance non-viral delivery technologies. The ideal candidate has strong technical expertise in LNP formulation, analytical characterization, and experimental data analysis, with a demonstrated ability to produce reproducible results in a biotechnology or pharmaceutical industry setting.
Key Responsibilities
- Lipid Nanoparticle Formulation: Develop, prepare, and optimize targeted and non-targeted lipid nanoparticles (LNPs and tLNPs) for nucleic acid delivery, including mRNA, siRNA, and DNA encapsulation.
- LNP Characterization: Perform physicochemical characterization of LNP formulations using Dynamic Light Scattering (DLS), zeta potential analysis, and Ribogreen assays to evaluate particle size, surface charge, and nucleic acid encapsulation efficiency.
- Design of Experiments (DoE): Execute DoE-based formulation screening campaigns to evaluate lipid compositions, formulation variables, and processing parameters to identify optimal LNP formulations.
- Formulation Development: Support early-stage formulation development, process optimization, and downstream processing activities, including cryoprotection, formulation scale-up, and stability studies.
- Targeted LNP Development: Support the preparation and characterization of targeted LNPs using antibody-based targeting ligands, including monoclonal antibodies (mAbs), Fab fragments, single-chain variable fragments (scFvs), and VHH antibodies.
- Cross-Functional Collaboration: Partner with internal research and development teams to coordinate formulation requests, meet project timelines, and support nucleic acid delivery studies.
- Data Analysis and Reporting: Analyze, interpret, and present formulation and characterization data to the Formulation team. Use Microsoft Excel and applicable statistical analysis software to evaluate experimental results and identify trends.
- Laboratory Documentation: Maintain accurate and detailed laboratory records, experimental protocols, formulation parameters, and results to support data integrity and reproducibility.
- Laboratory Operations: Perform routine laboratory management activities, including inventory tracking, supply ordering, buffer preparation, equipment maintenance, and autoclaving.
- Experimental Optimization: Troubleshoot formulation challenges, refine experimental procedures, and contribute to continuous improvement of LNP preparation and characterization workflows.
Required Qualifications
- Bachelor's degree in chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences, or a related scientific discipline,with at least 5 years of biopharmaceutical industry experience; or
- Master's degree in a related scientific discipline, with at least 2 years of biopharmaceutical industry experience.
- LNP Formulation Experience: Minimum of 2 years of hands-on laboratory experience in lipid nanoparticle formulation and nucleic acid encapsulation, including mRNA, siRNA, or DNA.
- Analytical Characterization: Demonstrated proficiency in LNP characterization techniques, including Dynamic Light Scattering (DLS), zeta potential measurement, and Ribogreen assays.
- Data Analysis: Advanced proficiency in Microsoft Excel for experimental data analysis, organization, and reporting.
- Experimental Design: Familiarity with formulation screening, experimental optimization, and Design of Experiments (DoE) methodologies.
- Laboratory Documentation: Ability to maintain detailed experimental records and generate accurate, reproducible laboratory data.
- Medical Coverage– HDHP, PPO, and Surest plan options
- Minimum Essential Coverage (MEC)
- Dental Insurance
- Vision Insurance
- Short-Term Disability (STD)
- Long-Term Disability (LTD)
- Life & AD&D Insurance
- Critical Illness Insurance
- Accident Insurance
- Employee Assistance Program (EAP)
Scientist II - LNP Formulation · Tailored Management