Scientist Bioscience - Proteomics

Scientist Bioscience - Proteomics

Location: Cambridge, MA

Onsite Flexibility: Onsite

Contract Details

• Position Type: Contract
• Contract Duration: 12 months
• Pay Rate: $40.00–$48.00 / Hour (USD)
• Work Authorization: Applicants must be authorized to work for ANY employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

Job Summary

We are seeking a highly motivated and talented scientist to join theChemical Biology and Proteomics group within Discovery Sciences. As a Research Scientist on a 12-month fixed-term contract, you will apply proteomics to advance drug discovery. You will work as an integral member of a cross-functional team to interrogate mechanisms of action for therapeutic agents, and to propose and validate biological hypotheses for agents within the cardiovascular, renal and metabolism (CVRM) area. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Key Responsibilities

• Design and execute discovery proteomic assays using mass spectrometry to support mechanistic studies, identify targets, and elucidate biological regulators of disease biology.
• Perform proximity biotinylation studies in cells, using established automated affinity purification workflows and data-independent acquisition (DIA) mass spectrometry methods.
• Perform target validation by developing proximity ligation assays (PLA) and cell-based assays to assess protein-protein interactions using chemical tools and confocal microscopy.
• Generate protein conjugates and characterize protein labeling by UV-Vis spectroscopy.
• Analyze and interpret experimental data using established bioinformatic pipelines.
• Maintain detailed and accurate electronic laboratory notebooks.
• Represent the CBP team, communicate with project discipline leads, and contribute to the generation of mechanistic hypotheses through interpretation of proteomics data.

Required Skills

• Hands-on proteomics experience (from graduate, postdoctoral, or industry work)
• Mammalian cell culture experience
• Data analysis skills
• Knowledge and hands-on experience with proteomic sample preparation
• Experience employing cell-based and proteomic assays to understand small molecule mechanisms of action
• Demonstrated ability to work effectively both independently and collaboratively, contribute to scientific discussions, solve problems, and deliver high-quality results within agreed timelines
• Similar workflows including mammalian cell culture, protein conjugation, purification, andUV-Vis spectroscopy characterization
• Carrying out advancedmass spectrometry-based proteomics with affinity enrichments
• Expected to operate with significantly higher independence than an Associate Scientist level

Preferred Skills

• Experience developing proximity ligation assays (PLA) or related proximity-based protein-protein interaction validation assays
• Experience using LC-MS/MS platforms and semi-automated instrumentation
• Experience using proteomics search and analysis tools, such as Spectronaut, Proteome Discoverer, MaxQuant, Skyline, and Xcalibur

Education Requirements

• Ph.D. in Proteomics, Chemical Biology, Biological Sciences, Biochemistry, or a related discipline, with at least two years of hands-on proteomics experience, including experience gained during doctoral or postdoctoral research
• OR a Master's degree with 3–5 years of hands-on proteomics experience (minimum 1 year of industry proteomics experience)

Required Experience

• Ph.D. with proteomics experience from graduate research or postdoctoral work, OR Master's degree with prior industry proteomics experience (minimum 1 year industry proteomics, 3–5 years hands-on lab experience)
• At least two years of hands-on proteomics experience (for Ph.D. candidates), including experience gained during doctoral or postdoctoral research
• Experience in mammalian cell culture

Nice-to-Have Experience

• Experience developing or applying proximity ligation assays or related proximity-based protein-protein interaction validation assays

Benefits

• Medical, Vision, and Dental Insurance Plans
• 401k Retirement Fund

About the Client

This globalbiopharmaceutical company is driven by a single, defining mission: to push the boundaries of science and deliver life-changing medicines that transform the lives of patients worldwide. With a global footprint spanning more than 100 countries, the organization focuses on three core therapy areas: oncology, cardiovascular and metabolic disease, and respiratory and immunology, while also advancing treatments in rare diseases and vaccines. Employing tens of thousands of scientists, clinicians, and business professionals globally, this organization combines the resource depth of a top-tier pharma company with a genuine culture of scientific curiosity, with research programs spanning small molecules, biologics, cell therapy, and RNA technologies. In 2026, employees voted this organization onto Glassdoor's Best Places to Work list, and it holds an overall Glassdoor rating of 4.0 stars from nearly 8,000 reviews — with 79% of employees saying they would recommend working here to a friend. Teams here span oncology researchers, clinical trial specialists, regulatory scientists, and commercial and market access professionals.

About GTT

GTT is a minority-owned staffing firm and a subsidiary of Chenega Corporation, a Native American-owned company in Alaska. We highly value diverse and inclusive workplaces and support Fortune 500 organizations across banking, financial services, technology, life sciences, biotech, utilities, and retail sectors throughout the U.S. and Canada.

Job Number: 26-15979

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