Head of In Vitro Pharmacology
Proteros Biostructures Gmbh
- 🇩🇪 Germany
- On-site
- Manager or above
- 1 week ago
- Shopify Liquid
- GLP
1 week ago
Not enough detail in this posting to match
- Establish all in vitro pharmacology capabilities and processes required for integrated drug discovery programs.
- Define and lead the required design, execution, and analysis ofcell-based assays to support hit identification, hit-to-lead, and lead optimization campaigns.
- Select, engineer, and characterize disease-relevant cell lines, including stable and transient transfection models.
- Providestrategic input into target selection and validation.
- Design strategies forhigh-throughput screening campaigns using advanced assay technologies (NanoBRET, NanoBiT, TR-FRET, AlphaScreen, luminescence, reporter gene activation, FLIPR and others).
- Apply molecular and cellular biology techniques (e.g., Western blot, qPCR, gene editing, siRNA knockdown, biomarker assays) to evaluate compound activity, efficacy, mechanism of action and pathway engagement.
- Ensurerobust experimental design, reproducibility, and data quality while meeting project timelines.
- Lead and mentor a team ofresearch associates and scientists to achieve operational and scientific excellence.
- Collaborate and communicate effectively withincross-functional drug discovery teams, including medicinal chemistry, biophysics, structural biology, protein sciences, and computational chemistry.
- Align scope, timelines and decision points for support of med chem optimization, and generate high-quality in vitro pharmacology data packages to support IND-enabling activities and candidate nomination decisions.
- Present scientific capabilities and findings tointernal stakeholders and external partners.
- Lead implementation ofautomation, liquid handling systems, and high-throughput assay processing to enhance team productivity and scalability.
- PhD in Cellular Biology, Pharmacology, Chemical Biology or a related discipline.
- 10+ years of industry experience in in vitro pharmacology within a small molecule drug discovery setting (biotech or pharmaceutical).
- Extensive expertise in cellular and molecular biology techniques.
- Proven track record of contributing to the progression of small molecule drug candidates from hit to candidate nomination.
- Hands-on experience withassay development for potency, efficacy, target engagement, selectivity, and mechanism of action of small molecules.
- Proficiency inmammalian cell culture (including establishing and maintaining transient and stable cell lines).
- Long-standing experience withliquid handling systems, automation, and high-throughput assay execution.
- Strong skills indata analysis, interpretation, and scientific communication.
- Demonstrated ability tomanage multiple projects in a fast-paced, dynamic research environment.
- Strong leadership skills with experience managingresearch associates and scientists.
- Excellentorganizational, written, and oral communication skills.
- Experience in one or more key disease areas, including oncology, immunology, neuroscience, or metabolic diseases.
Preferred
- Familiarity withCRO operating environment, including multi-client project management, resource planning, and client-facing scientific communication.
- Experience with targeted protein degradation modalities (PROTACs, molecular glues, bifunctional degraders).
- Knowledge of DMPK interface: protein binding, metabolic stability, and their impact on in vitro assay interpretation.
- Experience operating within an IND-enabling or GLP-compliant environment.
- An entrepreneurial scientific environment at a world-leading structure-based drug discovery CRO.
- A key leadership role with the mandate and resources to build a new pharmacology capability from the ground up.
- Close collaboration with expert teams in structural biology, biophysics, medicinal chemistry, and computational chemistry.
- Competitive remuneration package and opportunities for professional development.
- A dynamic, international, and scientifically driven team based in the Greater Munich area.
People Team
Bunsenstr. 7a, 82152 Martinsried
+49 89 700761 0
joinus@proteros.de
Head of In Vitro Pharmacology · Proteros Biostructures Gmbh