TM
SD_Scientist I
Tailored Management
🇺🇸 United States
On-site
Senior
4 weeks ago
$27.96 – $44.82 / hour
- Excel
- JMP
- Prism
4 weeks ago
Location: San Diego, CA 92111
Contract Duration: 3 Months (Potential for Extension or Full-Time Conversion)
Pay Rate: $27.96–$44.82/hour (W2)
Benefits: Weekly Pay, Medical, Dental, and Vision Insurance
Position Summary
We are seeking a motivated and detail-orientedScientist I to join our Formulation team. This is a hands-on laboratory position focused on theformulation, optimization, and characterization of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery.
The successful candidate will work closely with senior formulation scientists and cross-functional teams to support LNP development activities, generate high-quality and reproducible data, and contribute to the advancement of non-viral delivery platforms.
Key Responsibilities
- Execute and optimize theformulation and characterization of lipid nanoparticles (LNPs) and targeted LNPs (tLNPs) for encapsulation and delivery of nucleic acids in in vitro and in vivo studies, with guidance from senior formulation scientists.
- ConductDesign of Experiments (DoE)-based screening campaigns to evaluate and optimize LNP compositions and processing parameters.
- Collaborate with cross-functional internal teams to support formulation requests and project objectives.
- Support early-stage formulation development and downstream processing activities, including:
- Cryoprotection
- Scale-up
- Stability studies
- Other formulation development activities as needed
- Maintain accurate and detailed laboratory records, including formulation procedures, experimental conditions, and results.
- Analyze, interpret, and present experimental data to the formulation team.
- Support routine laboratory operations, including:
- Inventory tracking
- Supply ordering
- Buffer preparation
- Autoclaving
- General lab organization and maintenance
Required Qualifications
- Bachelor’s degree in chemistry, Biochemistry, Chemical Engineering, or a related scientific discipline with4+ years of biopharmaceutical industry experience,OR
- Master’s degree in a relevant scientific discipline with1+ years of biopharmaceutical industry experience.
- Minimum2 years of hands-on laboratory experience in LNP formulation, including nucleic acid encapsulation involvingmRNA, siRNA, or DNA.
- Hands-on experience with standardLNP characterization techniques, including:
- Dynamic Light Scattering (DLS)
- Zeta potential
- Ribogreen assays
- Strong proficiency withMicrosoft Excel for data analysis and reporting.
- Experience with statistical and data analysis software such asJMP or GraphPad Prism is preferred.
- Strong attention to detail and demonstrated ability to generateaccurate, reproducible experimental data.
- Excellent organizational, analytical, and communication skills.
- Ability to work effectively and collaboratively in afast-paced, cross-functional laboratory environment.
Preferred Qualifications
- Hands-on experience withtargeted LNP (tLNP) preparation, particularly LNPs coated with:
- Monoclonal antibodies (mAb)
- Fab fragments
- ScFv
- VHH
- Experience withimmune cell delivery using targeted or non-targeted LNP platforms.
- Experience supporting formulationscale-up, stability, and downstream processing activities.
- Familiarity with DoE-based formulation optimization and statistical analysis.
SD_Scientist I · Tailored Management