Senior Scientist – Asymmetric Catalysis and High-Throughput Experimentation

Senior Scientist –AsymmetricCatalysis and High-ThroughputExperimentation 

AstraZeneca is a global biopharmaceutical company focused on innovating and delivering life-saving medicines while prioritizing sustainability and minimizing our environmental impact. We foster a collaborative, inclusive culture where colleagues are empowered to share ideas and feel valued and rewarded. 

Pharmaceutical Technology & Development (PT&D) transformscutting-edge science into medicines for millions, working across the value chain to design, develop, and scale up drug products from early research through commercial manufacture. 

In Chemical Development, we combine scientificexpertise and innovation to create andoptimize sustainable, commerciallyviable processes for active pharmaceutical ingredients. By collaborating widely and embracingnew technologies, we continually improve how we deliver medicines. 

Catalysis and High-Throughput Experimentation (HTE)facilitate the development of efficient and sustainable processes, allowing innovative routes to API (Active Pharmaceutical Ingredient) molecules that are increasing in complexity. The catalysis and HTE group support the development and manufacture of drug projects across the portfolio, from late-discovery to launch, with keyexpertise in a range of technologies such as cross-coupling, asymmetric reactions, and the use of gases in synthesis.  

Job description: 

We are offering anexciting Senior Scientist position in asymmetric catalysis and HTEin our vibrantteam, with the successful candidate joining a cutting-edge pharmaceutical lab with access to gloveboxes andstate of the art HTE equipment. The responsibilities and requirements of the position are outlined below. 

The role is based at the Macclesfield Campus, Cheshire. 

Key responsibilities: 

• Lab based role involving the design and execution of catalytic reactions with the ability to interpret data, analyse results and plan the next steps accordingly. 

• Has a good understanding of reactions relevant to the pharmaceutical industry and anup-to-date knowledge of the literature inrelevant areas ofasymmetriccatalysis and synthesis. 

• Seeks out the mostappropriate methods for carrying out experimental work to a high standardutilizinghigh-pressure equipment,high-throughputexperimentationandautomation whereappropriate. 

• Collaborates with other members of the catalysis team, drug projectteams or external academic collaboratorsto contribute to the development of new medicines. 

Essential Requirements: 

• A PhDaligned to organic synthesis and/or catalysis, or BSc/MSc with relevant industrial experience to an equivalent level. 

• Experience in high-throughput experimentation (HTE) and running pressure reactions, with a strong understanding of safe laboratory practices and relevant experimental procedures. 

• An excellent understanding of synthetic reagents and methodologies, reactionmechanisms and modern analytical techniques. 

• A record of scientific innovation, throughpublicationauthorship,patentinventorship, or conference presentation. 

• The ability to workeffectivelywithin a team environment.  

Desirable experience and attributes: 

• Lab-based pharmaceutical industry and/or process development experience with awareness of considerations for design of synthetic routes for scale-up and manufacture of APIs. 

• The confidence to coach and drive performance and development among your peers. 

• Excellent communication skills, with the ability to communicate across interfaces ofscientificdisciplines, culture, andexpertise both internally and externally. 

Please note applications must include your current CV and acovering letter which presentsyour key areas of strength and why you should be considered for the role. 

​Why AstraZeneca? 

Make a more meaningful impact to patients’ lives around the globe 

With science at its heart, this is where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem. 

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward as we lead the way for healthcare and society. 

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development

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