Company Overview

Holostem Srl is a pioneering biotechnology company specialising inAdvanced Therapy Medicinal Products (ATMPs) and regenerative medicine. The company is best known for the development and commercialization ofHoloclar®, thefirst stem cell–based ATMP to receive centralized marketing authorization from the European Medicines Agency (EMA).

Building on the success of Holoclar®, Holostem continues to advance innovative cell‑based therapies addressing severe unmet medical needs, working closely with treatment centres, regulators, and scientific partners across Europe and internationally.

Holostem s.r.l. website
www.holostem.com

Location

Italy (with extensive European and international travel)

Reporting Line

Chief Operating Officer (COO)

Role Purpose

The Business Development & Sales Manager will drivecommercial growth and strategic expansion for Holostem’s ATMP portfolio, includingHoloclar® and pipeline assets. The role combinesbusiness development, sales execution, and strategic partnership development, with a strong focus ontreatment centre engagement,market access, andregulatory‑aware commercialisation models specific to ATMPs.

The successful candidate will act as a key interface betweencommercial strategy and operational delivery, leveraging Holostem’s experience with Holoclar® as a benchmark for excellence in ATMP market access, supply coordination, and stakeholder engagement.

Key Responsibilities

Commercial & Business Development

Implementbusiness development and commercial strategies as agreed with the Chief Operating Officer, building on the proven commercialization framework established withHoloclar®.
Drivesales performance in assigned territories, supporting adoption of Holostem therapies at authorised and emerging treatment centres.
Identify, qualify, and onboardnew treatment centres, ensuring readiness in line with ATMP regulatory and operational requirements.
Define, negotiate, and maintainsupply and commercial agreements with treatment centres, reflecting the controlled supply and traceability models required for products such as Holoclar®.
Ensureaccurate forecasting and demand planning, aligned with manufacturing capacity and clinical scheduling.

Strategic Growth & Market Expansion

Identify and evaluatestrategic growth opportunities across European and selected international markets, including:

Partnerships and institutional collaborations
Licensing and co‑development opportunities
Distribution and access models tailored to ATMPs

Scout and analyseregulatory, competitive, and reimbursement environments, using the Holoclar® experience as a reference point for risk mitigation and opportunity assessment.
Propose and implementmarket‑specific strategies that support sustainable expansion while maintaining compliance with EMA and national frameworks.

Stakeholder & Relationship Management

Build and maintain strong relationships withkey stakeholders at treatment centres, including clinicians, surgeons, pharmacists, procurement teams, and hospital management.
Act as atrusted commercial and scientific partner, supporting appropriate patient access to Holoclar® and future therapies.
Ensure consistent engagement withkey opinion leaders (KOLs) in regenerative medicine and ATMPs.

Cross‑Functional Collaboration

Collaborate closely withScientific, Regulatory, Quality, Client Services, Manufacturing, Clinical, Supply Chain, and Finance teams to:

Align commercial opportunities with operational and manufacturing readiness
Support regulatory compliance and post‑authorization commitments linked to Holoclar®
Ensuretimely, compliant delivery of therapies to treatment centres

Support internal decision‑making with market insights derived from field activities.

External Representation

Represent Holostem atinternational conferences, scientific congresses, partnering events, and investor meetings, positioning Holoclar® as a reference ATMP success story.
Increase company visibility and generatequalified commercial and strategic leads across Europe and beyond.

Qualifications & Experience

Education

PhD in Life Sciences or a relevant scientific discipline (required).
MBA or equivalent business education is a plus but not mandatory.

Professional Experience

Proven experience inbusiness development, sales, or strategic consultancy within biotech, pharma, or advanced therapies.
Direct experience withATMPs, regenerative medicine, stem cell or cell‑based therapies; familiarity with Holoclar® or similar hospital‑based ATMP models is a strong advantage.
Solid understanding of theEMA regulatory framework, including centralized authorization and post‑marketing obligations.

Technical & Business Skills

Knowledge ofpharmaceutical and ATMP operations, including manufacturing‑commercial interfaces.
Experience withforecasting, contract negotiation, and partnership structuring.
Ability to assesscomplex regulatory and market environments and translate insights into actionable commercial strategies.
Basic computer literacy; experience with CRM and reporting tools preferred.

Language Requirements

Fluent written and spoken English (mandatory).
Fluent written and spoken Italian (mandatory).
Additional European languages are a plus.

Personal Attributes

Strategic yet hands‑on mindset, comfortable operating in ahigh‑innovation, regulated ATMP environment.
Strong interpersonal and negotiation skills, with the ability to engage credibly with scientific, clinical, and executive stakeholders.
High level of autonomy, resilience, and willingness to travel extensively.
Strong ethical standards and commitment to patient‑centric commercialisation.

What Holostem Offers

A pivotal role in a company with alandmark ATMP success story (Holoclar®) and an expanding pipeline.
Exposure to cutting‑edge regenerative medicine and advanced cell‑based therapies.
Direct interaction with senior leadership and influence on commercial and corporate strategy.
Competitive compensation package aligned with experience and performance.

Privacy
Privacy Policy - Holostem S.r.l.

Application
Application must be submitted by the 10th May 2026 to the following link:https://apply.workable.com/
The position is open to both genders (L.903/77 – D.Lgs. n.198/2006)

Holostem S.r.l remote jobs

Business Development & Sales Manager

Responsabile Ingegneria e Manutenzione

Chief Financial Officer